Development of a Novel Canine Model for Posttraumatic Osteoarthritis of the Knee.

The journal of knee surgery

PubMedID: 25892003

Brimmo OA, Pfeiffer F, Bozynski CC, Kuroki K, Cook C, Stoker A, Sherman SL, Monibi F, Cook JL. Development of a Novel Canine Model for Posttraumatic Osteoarthritis of the Knee. J Knee Surg. 2015;.
Translational models of posttraumatic osteoarthritis (PTOA) that accurately represent clinical pathology need to be developed. This study assessed a novel canine model for PTOA using impact injury. Impacts were delivered to the medial femoral condyle of dogs using a custom-designed impactor at 20, 40, or 60 MPa. Functional assessments and magnetic resonance imaging (MRI) were performed at 2 and 12 weeks, and arthroscopic and histologic assessments were performed at 12 weeks after injury. At 2 and 12 weeks, dogs had observable lameness, knee pain, effusion, loss in range of motion (ROM) and dysfunction in both hindlimbs with severity correlated strongly (r?>?0. 77) to impact level. At 12 weeks, function, pain, effusion, and ROM were significantly (p?