Energy dependence of the complexity of DNA damage induced by carbon ions.

Radiation protection dosimetry

PubMedID: 25958411

Alloni D, Baiocco G, Babini G, Friedland W, Kundrát P, Mariotti L, Ottolenghi A. Energy dependence of the complexity of DNA damage induced by carbon ions. Radiat Prot Dosimetry. 2015;.
To assess the complexity of DNA damage induced by carbon ions as a function of their energy and LET, 2-Gy irradiations by 100 keV u(-1)-400 MeV u(-1) carbon ions were investigated using the PARTRAC code. The total number of fragments and the yield of fragments of <30 bp were calculated. The authors found a particularly important contribution of DNA fragmentation in the range of <1 kbp for specific energies of <6 MeV u(-1). They also considered the effect of different specific energies with the same LET, i. e. before and after the Bragg peak. As a first step towards a full characterisation of secondary particle production from carbon ions interacting with tissue, a comparison between DNA-damage induction by primary carbon ions and alpha particles resulting from carbon break-up is presented, for specific energies of >1 MeV u(-1).