Taking a low glycemic index multi-nutrient supplement as breakfast improves glycemic control in patients with type 2 diabetes mellitus: a randomized controlled trial.

Nutrients

PubMedID: 25514391

Li D, Zhang P, Guo H, Ling W. Taking a low glycemic index multi-nutrient supplement as breakfast improves glycemic control in patients with type 2 diabetes mellitus: a randomized controlled trial. Nutrients. 2014;6(12):5740-55.
Dietary therapy is the mainstay of treatment for diabetes. This study examined the effect of a low glycemic index (GI) multi-nutrient supplement, consumed in place of breakfast, on glycemic control in patients with type 2 diabetes mellitus (T2DM). A total of 71 participants were randomized at a 2:1 ratio into either a breakfast replacement group or a normal breakfast group for a 12-week interventional study. The primary outcome measure was change in hemoglobin A1c (HbA1c). Nutrition status and somatometry were studied as secondary outcomes. The breakfast replacement group displayed a -0. 2% absolute reduction in HbA1c (95% CI (confidence interval), -0. 38% to -0. 07%, p = 0. 004), while the HbA1c of the control group increased 0. 3% (95% CI, 0. 1% to 0. 5%, p = 0. 005). The baseline Mini Nutritional Assessment score for both groups was 26. 0 and no significant changes occurred following intervention. However, there was a statistically significant difference in body mass index between the treatment and control groups (p = 0. 032) due to the weight gain in the control group (increased 0. 5 kg, 95% CI was 0. 2 to 0. 9, p = 0. 007). These data suggest that breakfast replacement with a low GI multi-nutrient supplement can improve glycemic and weight control in T2DM.