Influence of simvastatin on dopaminergic neurons of lipopolysaccharide-induced rat model of Parkinson's disease.

Asian Pacific journal of tropical medicine

PubMedID: 25901927

Wang T, Cao XB, Chen XW, Huang PP, Zhang T, Chen ZB, Tang BS. Influence of simvastatin on dopaminergic neurons of lipopolysaccharide-induced rat model of Parkinson's disease. Asian Pac J Trop Med. 2015;8(1):64-7.
OBJECTIVE
To investigate the neuroprotective effects of simvastatin on lipopolysaccharide (LPS)-induced rat model of Parkinson's disease (PD) and the mechanisms involved.

METHODS
Hemiparkinsonian rat models were induced by stereotaxieal injection of LPS in the right substantia nigra compacta. After 2 weeks of simvastatin treatment, rotational behavior test was performed after the intraperitoneal injection of apomorphine. Expression of tyroxine hydroxylase (TH) and glial fibrillary acidic protein were analyzed through immunohistochemical staining of substantia nigra and striatum, and the level of TNF- a was evaluated using enzyme-linked immunosorbent assay.

RESULTS
Comparing with untreated group, behavioral symptoms of the rats were significantly less in the rats that received simvastatin treatment. The TH positive cell count in substantia nigra and striatum were significantly increased (P<0.05) and TNF- a expression was significantly decreased (P<0.05) in simvastatin group compared to untreated group.

CONCLUSIONS
Simvastatin could effectively inhibit the activation of astrocytes, reduce TNF- a expression, and exert anti-inflammatory effects, and thus protect the dopaminergic neurons in substantia nigra and striatum of the rat model of PD.