Hypoxia inducible factor 1a expression and effects of its inhibitors in canine lymphoma.

The Journal of veterinary medical science / the Japanese Society of Veterinary Science

PubMedID: 26050843

Kambayashi S, Igase M, Kobayashi K, Kimura A, Shimokawa-Miyama T, Baba K, Noguchi S, Mizuno T, Okuda M. Hypoxia inducible factor 1a expression and effects of its inhibitors in canine lymphoma. J Vet Med Sci. 2015;.
Hypoxic conditions in various cancers are believed to relate with their malignancy, and hypoxia inducible factor-1a (HIF-1a) has been shown to be a major regulator of the response to low oxygen. In this study, we examined HIF-1a expression in canine lymphoma using cell lines and clinical samples and found that these cells expressed HIF-1a. Moreover, the HIF-1a inhibitors, echinomycin, YC-1 and 2-methoxyestradiol, suppressed the proliferation of canine lymphoma cell lines. In a xenograft model using NOD/scid mice, echinomycin treatment resulted in a dose-dependent regression of the tumor. Our results suggest that HIF-1a contributes to the proliferation and/or survival of canine lymphoma cells. Therefore, HIF-1a inhibitors may be potential agents to treat canine lymphoma.