Chocolate Consumption and Risk of Atrial Fibrillation (from the Physicians' Health Study).

The American journal of cardiology

PubMedID: 26076989

Khawaja O, Petrone AB, Kanjwal Y, Gaziano JM, Djoussé L. Chocolate Consumption and Risk of Atrial Fibrillation (from the Physicians' Health Study). Am J Cardiol. 2015;.
Chocolate consumption has been shown to protect against various cardiovascular end points; however, little is known about the association between chocolate consumption and incident atrial fibrillation (AF). Therefore, we prospectively examined the association between chocolate consumption and incident AF in a cohort of 18,819 US male physicians. Chocolate consumption was ascertained from 1999 to 2002 through a self-administered food frequency questionnaire. Incident AF was ascertained through yearly follow-up questionnaires. Cox regression was used to estimate relative risks of AF. The average age at baseline was 66 years (±9. 1). During a mean follow-up of 9. 0 years (±3. 0), 2,092 cases of AF occurred. Using <1 per month of chocolate consumption as the reference group, multivariable adjusted hazard ratios (95% confidence interval) for AF were 1. 04 (0. 93 to 1. 18), 1. 10 (0. 96 to 1. 25), 1. 14 (0. 99 to 1. 31), and 1. 05 (0. 89 to 1. 25) for chocolate intake of 1 to 3 per month and 1, 2 to 4, and =5 per week (p for trend 0. 25), respectively. In a secondary analysis, there was no evidence of effect modification by adiposity (p interaction = 0. 71) or age (p interaction = 0. 26). In conclusion, our data did not support an association between chocolate consumption and risk of AF in US male physicians.