The Pro-inflammatory Cytokine Interleukin-1ß is a Key Regulatory Factor for the Postictal Suppression in Mice.

CNS neuroscience & therapeutics

PubMedID: 26096304

Tao AF, Xu ZH, Chen B, Wang Y, Wu XH, Zhang J, Tang YS, Xu CL, Zhao HW, Hu WW, Shi LY, Zhang SH, Chen Z. The Pro-inflammatory Cytokine Interleukin-1ß is a Key Regulatory Factor for the Postictal Suppression in Mice. CNS Neurosci Ther. 2015;.
AIMS
The postictal suppression (PS) is a common and important period following an epileptic seizure but has not been well studied. This study was designed to determine whether interleukin-1ß (IL-1ß) is involved in the PS.

METHODS
The effects of IL-1ß on the PS were tested in three independent seizure models induced by hippocampal kindling, maximal electroshock seizure (MES), and 4-aminopyridine, respectively.

RESULTS
IL-1R1 knockout or IL-1RA enhanced the seizure refractory phenomenon without influencing the baseline seizure threshold in intermittent MES model. IL-1ß attenuated the seizure refractory phenomenon without affecting the severity of the preceding seizures in hippocampal kindling model, while IL-1RA enhanced it. Besides, IL-1ß reduced the postictal EEG suppression period, while IL-1RA prolonged it. And IL-1ß showed no further effect on the postictal EEG suppression and seizure refractory phenomenon in IL-1R1 knockout mice. In addition, 30 min after intrahippocampal injection of 4-aminopyridine, IL-1ß increased the incidence of SE, while IL-1RA prolonged the intervals between recurrent seizures.

CONCLUSIONS
This study provides the first direct evidence that IL-1ß is key regulatory factor for the PS, and its receptor IL-1R1 may be a potential target for adjuvant treatment of postictal problems.