Mid-Term Results of Valve-Sparing Aortic Root Replacement in Patients With Expanded Indications.

The Annals of Thoracic Surgery

PubMedID: 26095104

Miyahara S, Matsueda T, Izawa N, Yamanaka K, Sakamoto T, Nomura Y, Morimoto N, Inoue T, Matsumori M, Okada K, Okita Y. Mid-Term Results of Valve-Sparing Aortic Root Replacement in Patients With Expanded Indications. Ann Thorac Surg. 2015;.
BACKGROUND
The mid-term results of valve-sparing aortic root reimplantation (VSRR) for various indications were investigated.

METHODS
From 2000 to 2013, 183 consecutive patients undergoing VSRR were enrolled. Expanded indications, defined as a patient on the marginal operative indication, included age 65 years or older (n = 33), age 15 years or younger (n = 4), acute type A aortic dissection (AAAD) (n = 21), aortitis (n = 8), reoperative root replacement (n = 11), cusp prolapse (n = 67), large aortoventricular junction of greater than 28 mm (AVJ) (n = 42), preoperative severe aortic regurgitation (AR) (n = 89), left ventricular ejection fraction 0.40 or less (n = 12), LV dilation (n = 66), New York Heart Association class III or greater (n = 5), need for total arch replacement (n = 29), and concomitant mitral valve repair (n = 12).

RESULTS
The overall survival at 5 years was 96.6%. Freedom from greater than mild AR and reoperation at 5 years was 85.8% and 92.9%, respectively. Cox proportional hazard model revealed that AAAD, cusp prolapse, AVJ 28 mm or greater, and operation before 2009 were at risk for late AR recurrence (p = 0.015, p = 0.0041, p = 0.032, and p = 0.014, respectively). After 2009, freedom from late AR in the cusp prolapse group improved (p = 0.055, versus control). Both freedom from recurrent AR and reoperation were worse as the number of expanded indications increased (log-rank trend p = 0.00017 and p = 0.00067, respectively).

CONCLUSIONS
Surgical outcomes of VSRR in these patient cohorts were satisfactory with some room for improvement in patients with cusp prolapse. Although the indications for VSRR are being expanded, a larger number of expanded indications were associated with poor outcomes in terms of longevity of valve function.