Next Generation of Preclinical Liver Cancer Models.

Clinical Cancer Research

PubMedID: 26169964

Weber A, O'Connor T, Heikenwalder M. Next Generation of Preclinical Liver Cancer Models. Clin Cancer Res. 2015;21(19):4254-6.
Because of its heterogeneity, lack of prognostic markers, tumor-escape mechanisms, and frequent relapse upon surgical intervention, treatment of hepatocellular carcinoma (HCC) remains challenging. In this issue of Clinical Cancer Research, Groß and colleagues characterize a rodent model that might help identify novel drugs for combinatorial sorafenib-based therapies for HCC. Clin Cancer Res; 21(19); 4254-6. ©2015 AACR. See related article by Groß et al. , p. 4440.