Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis.

Angewandte Chemie (International ed. in English)

PubMedID: 26180027

Zhu Z, Guan Z, Liu D, Jia S, Li J, Lei Z, Lin S, Ji T, Tian Z, Yang CJ. Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis. Angew Chem Int Ed Engl. 2015;.
Herein, we demonstrate that a very familiar, yet underutilized, physical parameter-gas pressure-can serve as signal readout for highly sensitive bioanalysis. Integration of a catalyzed gas-generation reaction with a molecular recognition component leads to significant pressure changes, which can be measured with high sensitivity using a low-cost and portable pressure meter. This new signaling strategy opens up a new way for simple, portable, yet highly sensitive biomedical analysis in a variety of settings.