Treatment of canine generalized demodicosis using weekly injections of doramectin: 232 cases in the USA (2002-2012).

Veterinary dermatology

PubMedID: 26190685

Hutt JH, Prior IC, Shipstone MA. Treatment of canine generalized demodicosis using weekly injections of doramectin: 232 cases in the USA (2002-2012). Vet Dermatol. 2015;.
BACKGROUND
Generalized demodicosis is a severe skin disease in the dog, with limited treatment options.

HYPOTHESIS/OBJECTIVES
To demonstrate that doramectin, when given at a dose rate of 0.6 mg/kg body weight, is a safe and effective treatment for generalized demodicosis in the dog.

ANIMALS
Four hundred client-owned dogs diagnosed with generalized demodicosis at one general small-animal practice. Of these, 232 completed their treatment and were included in the study.

METHODS
A retrospective study was carried out by searching the computerised medical records of dogs seen at one general small-animal practice in Tennessee, USA. The records of each dog with a diagnosis of generalized demodicosis, who underwent treatment using weekly injections of doramectin at a dose rate of 0.6 mg/kg body weight, were analysed.

RESULTS
Remission was achieved in 94.8% of dogs treated with weekly subcutaneous injections of doramectin at a dose rate of 0.6 mg/kg body weight. Adverse events were rare with two suspected instances (0.5%) being recorded. The mean duration of treatment was 7.1 weeks.

CONCLUSIONS AND CLINICAL IMPORTANCE
Doramectin given at a dose rate of 0.6 mg/kg body weight by subcutaneous injection at weekly intervals is a useful and well-tolerated treatment for generalized demodicosis in the dog.