Direct Ruthenium-Catalyzed Hydrogenation of Carboxylic Acids to Alcohols.

Angewandte Chemie (International ed. in English)

PubMedID: 26190772

Cui X, Li Y, Topf C, Junge K, Beller M. Direct Ruthenium-Catalyzed Hydrogenation of Carboxylic Acids to Alcohols. Angew Chem Int Ed Engl. 2015;.
The "green" reduction of carboxylic acids to alcohols is a challenging task in organic chemistry. Herein, we describe a general protocol for generation of alcohols by catalytic hydrogenation of carboxylic acids. Key to success is the use of a combination of Ru(acac)3 , triphos and Lewis acids. The novel method showed broad substrate tolerance and a variety of aliphatic carboxylic acids including biomass-derived compounds can be smoothly reduced.