Iterative Syntheses-The Gateway to New Automation Protocols.

Angewandte Chemie (International ed. in English)

PubMedID: 26189755

Hartwig J, Kirschning A. Iterative Syntheses-The Gateway to New Automation Protocols. Angew Chem Int Ed Engl. 2015;.
Automation is back on the agenda! The first automated iterative C?C coupling processes exploit the two faces of N-methyliminodiacetic acid boronates. They highlight the opportunities and challenges of how iterative synthesis with complex bifunctional building blocks can be conducted with liquid-handling devices to even access complex natural products.