Haplotypes in the promoter region of the CIDEC gene associated with growth traits in Nanyang cattle.

Scientific reports

PubMedID: 26189824

Wang J, Hua LS, Pan H, Zhang LZ, Li MX, Huang YZ, Li ZJ, Lan XY, Lei CZ, Li CJ, Chen H. Haplotypes in the promoter region of the CIDEC gene associated with growth traits in Nanyang cattle. Sci Rep. 2015;512075.
Cell death-inducing DFFA-like effector c (CIDEC, also known as Fsp27) has emerged as an important regulator of metabolism associated with lipodystrophy, diabetes, and hepatic steatosis. It is required for unilocular lipid droplet formation and optimal energy storage. The mechanism between this gene and livestock growth traits, however, has yet to be reported. In this study, we found ten novel single nucleotide polymorphisms (SNPs) in the 5' transcriptional region of CIDEC in Nanyang (NY) cattle, which are located in the recognition sequences (potential cis-acting elements) of 22 transcription factors, and the nine haplotypes represent nine different combinations of polymorphic potential cis-acting elements. THE RESULTS
indicated that individuals with the H8-H8 diplotype had heavier body weights and faster growth rates (P?