Causes of hypoamylasaemia in a hospital population.

Scandinavian journal of clinical and laboratory investigation

PubMedID: 26203959

Curd R, Crook MA. Causes of hypoamylasaemia in a hospital population. Scand J Clin Lab Invest. 2015;1-3.
AIMS
We noted serum amylase activity results in our laboratory that fell below the lower reference limit, although there was no obvious explanation for this and the literature on this topic is relatively sparse.

METHODS
We studied hospital laboratory requests and reports of individuals showing hypoamylasaemia over a one-year period.

RESULTS
We report one of the few studies to look at hypoamylasaemia in a hospital population. We found that 5.4% of the hospital serum amylase activity results were below the reference range quoted by our laboratory.

CONCLUSIONS
Some of the associations we observed with hypoamylasaemia were diabetes mellitus, cystic fibrosis, hypertriglyceridaemia and use of the antibiotic gentamicin. We suggest that clinicians and laboratories should be aware of the causes of hypoamylasaemia to aid interpretation of abnormally low amylase activity in their patients.