The Activation and Function of Autophagy in Alcoholic Liver Disease.

Current molecular pharmacology

PubMedID: 26278385

Khambu B, Wang L, Zhang H, Yin XM. The Activation and Function of Autophagy in Alcoholic Liver Disease. Curr Mol Pharmacol. 2015;.
Alcoholic liver disease (ALD) is caused by chronic alcohol abuse and is a serious health concern worldwide. ALD is characterized by steatosis, inflammation, fibrosis, which can progrss to cirrhosis. It is generally considered that the pathogenesis of ALD is intimately related to oxidative stress, derived from reactive intermediates, including acetaldehyde, increased NADH/NAD+ ratio and ROS generation [1-4] (Fig 1). An increased level of fatty acids and ROS may result in lipid peroxidation and increased production of inflammatory cytokines, which can contribute to liver injury and fibrosis. Autophagy plays important roles in mitigating ethanol-induced hepatocyte apoptosis and liver injury [5].