The stool microbiota of insulin resistant women with recent gestational diabetes, a high risk group for type 2 diabetes.

Scientific reports

PubMedID: 26279179

Fugmann M, Breier M, Rottenkolber M, Banning F, Ferrari U, Sacco V, Grallert H, Parhofer KG, Seissler J, Clavel T, Lechner A. The stool microbiota of insulin resistant women with recent gestational diabetes, a high risk group for type 2 diabetes. Sci Rep. 2015;513212.
The gut microbiota has been linked to metabolic diseases. However, information on the microbiome of young adults at risk for type 2 diabetes (T2D) is lacking. THE AIM
of this cross-sectional analysis was to investigate whether insulin resistant women with previous gestational diabetes (pGDM), a high risk group for T2D, differ in their stool microbiota from women after a normoglycemic pregnancy (controls).Bacterial communities were analyzed by high-throughput 16S rRNA gene sequencing using fecal samples from 42 pGDM and 35 control subjects 3-16 months after delivery.

CLINICAL
characterization included a 5-point OGTT, anthropometrics, clinical chemistry markers and a food frequency questionnaire.Women with a Prevotellaceae-dominated intestinal microbiome were overrepresented in the pGDM group (p?