Novel Equations for Estimating Lean Body Mass in Peritoneal Dialysis Patients.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

PubMedID: 26293839

Dong J, Li YJ, Xu R, Yang ZK, Zheng Y. Novel Equations for Estimating Lean Body Mass in Peritoneal Dialysis Patients. Perit Dial Int. 2015;.
UNLABELLED
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OBJECTIVES
To develop and validate equations for estimating lean body mass (LBM) in peritoneal dialysis (PD) patients. ?

METHODS
Two equations for estimating LBM, one based on mid-arm muscle circumference (MAMC) and hand grip strength (HGS), i.e., LBM-M-H, and the other based on HGS, i.e., LBM-H, were developed and validated with LBM obtained by dual-energy X-ray absorptiometry (DEXA). The developed equations were compared to LBM estimated from creatinine kinetics (LBM-CK) and anthropometry (LBM-A) in terms of bias, precision, and accuracy. The prognostic values of LBM estimated from the equations in all-cause mortality risk were assessed. ?

RESULTS
The developed equations incorporated gender, height, weight, and dialysis duration. Compared to LBM-DEXA, the bias of the developed equations was lower than that of LBM-CK and LBM-A. Additionally, LBM-M-H and LBM-H had better accuracy and precision. The prognostic values of LBM in all-cause mortality risk based on LBM-M-H, LBM-H, LBM-CK, and LBM-A were similar. ?

CONCLUSIONS
Lean body mass estimated by the new equations based on MAMC and HGS was correlated with LBM obtained by DEXA and may serve as practical surrogate markers of LBM in PD patients.