3-Aza p-allyl palladium derived from imino migration in palladium-carbene: MCRs toward multiple substituted indole skeleton.

Chemical communications (Cambridge, England)

PubMedID: 26299208

Dai Q, Jiang Y, Guo S, Yu JT, Cheng J. 3-Aza p-allyl palladium derived from imino migration in palladium-carbene: MCRs toward multiple substituted indole skeleton. Chem Commun (Camb). 2015;.
Palladium-catalyzed multi-component reactions (MCRs) between 2-iodoaniline, aryl isonitrile, N-tosylhydrazones and solvent were developed. This procedure features the migration of the imino group in palladium-carbene to produce a 3-aza p-allyl palladium species. Then, intramolecular nucleophilic attack of the p-allyl palladium species by the amino group takes place facilely, thus producing a 1,2,3-trisubstitued indole skeleton, which has high diversity and complexity.