Inhibitors of BCATm: A Tough Nut To Crack.

Journal of medicinal chemistry

PubMedID: 26339805

Scanlon M. Inhibitors of BCATm: A Tough Nut To Crack. J Med Chem. 2015;.
Inhibitors of the mitochondrial branched chain aminotransferase may have therapeutic potential in the treatment of diet-induced obesity and dyslipidemia. To explore the pharmacology of this metabolic pathway requires a potent and selective molecule that is well tolerated and has appropriate pharmacokinetic properties. The combination of fragment-based and high-throughput screening with structure-guided compound elaboration has yielded a tool compound that may serve as a chemical probe of this pathway.