Genetic Testing in the Multidisciplinary Management of Melanoma.

Surgical oncology clinics of North America

PubMedID: 26363541

Rashid OM, Zager JS. Genetic Testing in the Multidisciplinary Management of Melanoma. Surg Oncol Clin N Am. 2015;24(4):779-93.
Melanoma is increasing in incidence and represents an aggressive type of cancer. Efforts have focused on identifying genetic factors in melanoma carcinogenesis to guide prevention, screening, early detection, and targeted therapy. This article reviews the hereditary risk factors associated with melanoma and the known molecular pathways and genetic mutations associated with this disease. This article also explores the controversies associated with genetic testing and the latest advances in identifying genetic targets in melanoma, which offer promise for future application in the multidisciplinary management of melanoma.