Apolipoprotein A5 and apolipoprotein C3 single nucleotide polymorphisms are correlated with an increased risk of coronary heart disease: a case-control and meta-analysis study.

Lipids in health and disease

PubMedID: 26387083

Yang G, Lei MM, Yu CL, Liu XX, An Z, Song CL. Apolipoprotein A5 and apolipoprotein C3 single nucleotide polymorphisms are correlated with an increased risk of coronary heart disease: a case-control and meta-analysis study. Lipids Health Dis. 2015;14(1):113.
BACKGROUND
Triglycerides (TGs) are proatherogenic lipoproteins involving the risk of coronary heart disease (CHD), while apolipoprotein A5 (APOA5) and apolipoprotein C3 (APOC3) are main lipoproteins composing TG-rich lipoproteins. In this study, we aim to explore the correlation of CHD with APOA5 -1131 T?>?C and APOC3 -455 T?>?C single nucleotide polymorphisms (SNPs).

METHODS
A sum of 210 CHD patients, hospitalized between Jan. 2013 and Mar. 2015 at China-Japan Union Hospital, Jilin University, were selected as our case group and 223 healthy individuals who had physical examination at same hospital at the same period were selected as control group. The frequency distribution of genotypes of APOA5 -1131 T?>?C and APOC3 -455 T?>?C SNPs were measured by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The Stata 12.0 software was utilized for statistical analyses.

RESULTS
There was no significant difference on age and sex between case and control group (P?>?0.05). History of smoking, drinking, hypertension and diabetes mellitus, body mass index and levels of TG and fasting blood sugar in case group were shown to be higher than control group (P??C and APOC3 -455 T?>?C in case group were higher compared to control group (both P??C and APOC3 -455 T?>?C SNPs are likely to increase the risk of CHD (both P?
CONCLUSION
APOA5 -1131 T?>?C and APOC3 -455 T?>?C SNPs may play potent roles in the development and progression of CHD.