Work-Related Asthma.

Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine

PubMedID: 26461873

Jolly AT, Klees JE, Pacheco KA, Guidotti TL, Kipen HM, Biggs JJ, Hyman MH, Bohnker BK, Thiese MS, Hegmann KT, Harber P. Work-Related Asthma. J Occup Environ Med. 2015;57(10):e121-9.
OBJECTIVE
Summarize developed evidence-based diagnostic and treatment guidelines for work-related asthma (WRA).

METHODS
Comprehensive literature reviews conducted with article critiquing and grading. Guidelines developed by a multidisciplinary expert panel and peer-reviewed.

RESULTS
Evidence supports spirometric testing as an essential early test. Serial peak expiratory flow rates measurement is moderately recommended for employees diagnosed with asthma to establish work-relatedness. Bronchial provocation testing is moderately recommended. IgE and skin prick testing for specific high-molecular weight (HMW) antigens are highly recommended. IgG testing for HMW antigens, IgE testing for low-molecular weight antigens, and nitric oxide testing for diagnosis are not recommended. Removal from exposure is associated with the highest probability of improvement, but may not lead to complete recovery.

CONCLUSION
Quality evidence supports these clinical practice recommendations. The guidelines may be useful to providers who diagnose and/or treat WRA.