[THE UNESTERIFIED AND FREE FATTY ACIDS OF BLOOD PLASMA, DISTAL AND PROXIMAL PART OF ARTERIAL BED, VEGETATIVE INNERVATION AND PATHOGENESIS OF METABOLIC ARTERIAL].

Klinicheskaia laboratornaia diagnostika

PubMedID: 26470432

Titov VN, Dmitriev V A . [THE UNESTERIFIED AND FREE FATTY ACIDS OF BLOOD PLASMA, DISTAL AND PROXIMAL PART OF ARTERIAL BED, VEGETATIVE INNERVATION AND PATHOGENESIS OF METABOLIC ARTERIAL]. Klin Lab Diagn. 2015;60(5):4-13.
The stages of phylogenesis were used as a basis for sequential formation of humoral (hormonal) regulation and later neurohumoral regulation. Hereinafter, under becoming of biological function of locomotion nervous regulation was formed. At late stages of phylogenesis under formation of closed system of blood circulation, biological function of adaptation began using under regulation (compensation) of biological reaction metabolism-micro-circulation (M-M) hydrodynamic pressure too on a par with phylogenetically earlier biological reactions of compensation and stress. It can be assumed that in phylogenesis physical factors (hydrodynamic pressure and thermogenesis or hyperpyrexia) became effective regulators of metabolism at the level of organism. If patient suffers from increasing of arterial pressure the questions to be answered are--what disorders of metabolism in vivo it is called to compensate, what biological function is disordered and how these disorders of metabolism can be detected and normalized. The initial disorders of biological reaction M-M can be developed in any paracrin cenosis of cells, organ or system of organs. If local regulation (compensation) at the level of paracrin cenosis under effect of humoral mediators turned out ineffective compensation will form at the level of organism under realization of hydraulic and hydrodynamic regulation of metabolism. This kind of regulation can be described as optimal only partly. Because of imperfection of hydrodynamic systemic regulation of metabolism, independently of in how many sets of paracrin cenosis in vivo occurs formation of a physiological biologic reaction M-M, with time in pathological process target organs will be involved primarily kidneys, brain and more rarely lungs and later on heart.