Optical Coherence Tomography of the Labial Salivary Glands Reveals Age-Related Differences in Women.

Clinical and translational science

PubMedID: 26530049

Nowak JK, Grulkowski I, Karnowski K, Wojtkowski M, Walkowiak J. Optical Coherence Tomography of the Labial Salivary Glands Reveals Age-Related Differences in Women. Clin Transl Sci. 2015;.
The labial minor salivary glands (LSGs) play a role in medical research and practice due to their superficial location and involvement in both systemic and localized diseases. Swept-source optical coherence tomography (OCT) is a noninvasive modality that enables in vivo, micrometer resolution, wide-field three-dimensional imaging in seconds. A purpose-built swept-source OCT instrument was employed to acquire three-dimensional datasets covering the area of 2. 43 cm(2) of the mucosa of the lower lip to the depth of 3. 4 mm in young (n = 14; mean age ± SD: 27 ± 3 years; body mass index [BMI] 20. 4 ± 2. 3 kg/m(2) ) and middle-aged women (n = 11; 54 ± 6 years; 25. 5 ± 3. 2 kg/m(2) ). Glandular tissue reflectivity mode (range 0-255; 86 ± 17 vs. 68 ± 12, p = 0. 005), average single LSG area in tissue sample (5. 26 ± 2. 62 mm(2) vs. 2. 87 ± 1. 26 mm(2) , p = 0. 011), and LSG surface filling factor (0. 23 ± 0. 13 vs. 0. 11 ± 0. 10, p = 0. 027) had higher values in younger than in middle-aged women. A correlation between BMI and glandular tissue reflectivity mode (Spearman's ? = -0. 60) was found (p = 0. 002). THE RESULTS
highlight the potential value of LSGs' OCT morphometry in research regarding ageing.