Development of New Strategies for Echinocandins: Progress in Translational Research.

Clinical Infectious Diseases

PubMedID: 26567276

Walsh TJ, Azie N, Andes DR. Development of New Strategies for Echinocandins: Progress in Translational Research. Clin Infect Dis. 2015;61 Suppl 6S601-3.
Echinocandins are N-acyl-substituted cyclic hexapeptides with potent in vitro and in vivo activity against Candida species that are used for primary treatment and prevention of candidemia and invasive candidiasis. Recent progress in the translational research of echinocandins has led to new approaches for treatment of central venous catheter Candida biofilms. Other studies have laid the experimental and clinical foundation for use of extended dosing intervals for administration of echinocandins in treatment and prevention of candidemia and invasive candidiasis.