An absolute calibration method of an ethyl alcohol biosensor based on wavelength-modulated differential photothermal radiometry.

The Review of scientific instruments

PubMedID: 26628164

Liu YJ, Mandelis A, Guo X. An absolute calibration method of an ethyl alcohol biosensor based on wavelength-modulated differential photothermal radiometry. Rev Sci Instrum. 2015;86(11):115003.
In this work, laser-based wavelength-modulated differential photothermal radiometry (WM-DPTR) is applied to develop a non-invasive in-vehicle alcohol biosensor. WM-DPTR features unprecedented ethanol-specificity and sensitivity by suppressing baseline variations through a differential measurement near the peak and baseline of the mid-infrared ethanol absorption spectrum. Biosensor signal calibration curves are obtained from WM-DPTR theory and from measurements in human blood serum and ethanol solutions diffused from skin. THE RESULTS
demonstrate that the WM-DPTR-based calibrated alcohol biosensor can achieve high precision and accuracy for the ethanol concentration range of 0-100 mg/dl.The high-performance alcohol biosensor can be incorporated into ignition interlocks that could be fitted as a universal accessory in vehicles in an effort to reduce incidents of drinking and driving.