[Expression of phosphofructokinase 1 protein and it's enzyme activity on nasopharyngeal carcinoma].

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

PubMedID: 26665455

Li S, Hong H, Du Z, Liu F, Yang Q, Gao C. [Expression of phosphofructokinase 1 protein and it's enzyme activity on nasopharyngeal carcinoma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015;29(16):1455-7.
OBJECTIVE
The aim of this study is to investigate the expression of phosphofructokinase 1 and it's enzyme activity in nasopharyngeal carcinoma biopsy samples.

METHOD
Sixty-one biopsy samples were detected, including 41 tissues from patients with nasopharyngeal carcinoma as experimental group and 20 tissues from patients with chronic nasopharyngitis as control group. Phosphofructokinase 1 protein was detected by Western blot and it's enzyme activity was detected.

RESULT
It was observed that the expression levels of phosphofructokinase 1 protein and it's enzyme activities in the experimental group were higher than that in the control group (P < 0.01). In the experimental group, the expression levels of phosphofructokinase 1 protein and it's enzyme activities in patients with lymph node metastasis were higher than that in patients without lymph node metastasis (P < 0.01).

CONCLUSION
Phosphofructokinase 1 may be a marker in occurrence and metastasis of nasopharyngeal carcinoma.