APOLIPOPROTEINS AND THEIR ASSOCIATION WITH CARDIOMETABOLIC RISK BIOMARKERS IN ADOLESCENTS.

Nutricion hospitalaria : organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral

PubMedID: 26667720

Neyla de Lima Albuquerque M, Da Silva Diniz A, Kruze Grande de Arruda I. APOLIPOPROTEINS AND THEIR ASSOCIATION WITH CARDIOMETABOLIC RISK BIOMARKERS IN ADOLESCENTS. Nutr Hosp. 2015;32(n06):2674-2683.
INTRODUCTION
the apoB/apo A-I ratio has been reported as an important predictor of cardiovascular risk, being superior to lipids, lipoproteins and conventional lipid ratios.

OBJECTIVE
to investigate the association between apolipoproteins A-I and B, and the apolipoprotein B/apolipoprotein A-I ratio and cardiometabolic risk variables in adolescents.

METHODS
this was a cross-sectional study including 104 adolescents of public schools in Recife during the months of March/April, 2013. Sociodemographic, anthropometric, clinical and biochemical variables were analysed. The apolipoproteins were analysed via Immunoturbidimetry.

RESULTS
body mass index, waist circumference, waist circumference/height, triglycerides, cholesterol/HDL, and apolipoprotein B/apolipoprotein A-I declined with the progress of the percentile distribution of apolipoprotein A-I concentrations, while the HDL and apolipoprotein B increased between the first and last quartiles of the apolipoprotein A-I concentrations. Systolic blood pressure, body mass index, waist circumference, waist circumference/height, cholesterol, LDL, triglycerides, cholesterol/HDL, and LDL/HDL increased progressively in the quartile distribution of the concentrations of apolipoprotein B and apolipoprotein B/apolipoprotein A-I. Alfa-1-acid glycoprotein serum levels increased hand-inhand with the percentile progression of apolipoprotein B.

CONCLUSIONS
the findings underline an important association of apolipoproteins A-I and B, and the apolipoprotein B/apolipoprotein A-I ratio and their clinical, biochemical and anthropometric cardiometabolic risk. However, prospective studies are important to evaluate the pertinence of implementing these markers in the clinical practice.