Refraction data survey: 2nd generation correlation of myopia.

International ophthalmology

PubMedID: 26757932

Greene PR, Medina A. Refraction data survey: 2nd generation correlation of myopia. Int Ophthalmol. 2016;.
The objective herein is to provide refraction data, myopia progression rate, prevalence, and 1st and 2nd generation correlations, relevant to whether myopia is random or inherited. First- and second-generation ocular refraction data are assembled from N = 34 families, average of 2. 8 children per family. From this group, data are available from N = 165 subjects. Inter-generation regressions are performed on all the data sets, including correlation coefficient r, and myopia prevalence [%]. Prevalence of myopia is [M] = 38. 5 %. Prevalence of high myopes with |R| >6 D is [M-] = 20. 5 %. Average refraction is  = -1. 84 D ± 3. 22 (N = 165). For the high myopes, |R| >6 D, prevalence for the parents is [M-] = 25 %, for the 2nd generation [M-] = 16. 5 %. Average myopia level for the high myopes, both generations, is  = -7. 52 D ± 1. 31 D (N = 33). Regression parameters are calculated for all the data sets, yielding correlation coefficients in the range r = 0. 48-0. 72 for some groups of myopes and high myopes, fathers to daughters, and mothers to sons. Also of interest, some categories show essentially no correlation, -0. 20 < r < 0. 20, indicating that the refractive errors occur randomly. Time series results show myopia diopter rates = -0. 50 D/year.