Pluripotency without Proliferation.


PubMedID: 26871623

Shu X, Pei D. Pluripotency without Proliferation. Cell. 2016;164(4):595-7.
Mouse embryonic stem cells (mESCs) are capable of unlimited proliferation without losing pluripotency. Scognamiglio et al. now reveal that Myc depletion shifts mESCs into a dormant state reminiscent of embryonic diapause in which pluripotency remains fully preserved, thus decoupling pluripotency from proliferative programs.