Salusin-ß as a powerful endogenous antidipsogenic neuropeptide.

Scientific reports

PubMedID: 26869388

Suzuki-Kemuriyama N, Nakano-Tateno T, Tani Y, Hirata Y, Shichiri M. Salusin-ß as a powerful endogenous antidipsogenic neuropeptide. Sci Rep. 2016;620988.
Salusin-ß is an endogenous parasympathomimetic peptide, predominantly localized to the hypothalamus and posterior pituitary. Subcutaneously administered salusin-ß (50?nmol/mouse) significantly increased water intake but did not affect locomotor activity or food intake. The salusin-ß-induced increase in water intake was completely abrogated by pretreatment with muscarinic antagonist, atropine sulphate. In contrast, intracerebroventricular injection of salusin-ß, at lower doses (10-100?fmol/mouse) caused a long-lasting decrease in water intake and locomotor activity throughout the entire dark phase of the diurnal cycle. Pre-injection of intracerebroventricular anti-salusin-ß IgG completely abrogated the central salusin-ß mediated suppression of water intake and locomotor activity. These results demonstrate contrasting actions of salusin-ß in the control of water intake via the central and peripheral systems and highlight it as a potent endogenous antidipsogenic neuropeptide.