Rhodium-catalyzed chemo- and regioselective decarboxylative addition of ß-ketoacids to alkynes.

Chemical communications (Cambridge, England)

PubMedID: 27040888

Li C, Grugel CP, Breit B. Rhodium-catalyzed chemo- and regioselective decarboxylative addition of ß-ketoacids to alkynes. Chem Commun (Camb). 2016;.
A highly efficient rhodium-catalyzed chemo- and regioselective addition of ß-ketoacids to alkynes is reported. Applying a Rh(i)/(S,S)-DIOP catalyst system, ?,d-unsaturated ketones were prepared with exclusively branched selectivity under mild conditions. This demonstrates that readily available alkynes can be an alternative entry to allyl electrophiles in transition-metal catalyzed allylic alkylation reactions.