Synchronous intramolecular cycloadditions of the polyene macrolactam polyketide heronamide C.

Chemical communications (Cambridge, England)

PubMedID: 27091090

Booth TJ, Alt S, Capon RJ, Wilkinson B. Synchronous intramolecular cycloadditions of the polyene macrolactam polyketide heronamide C. Chem Commun (Camb). 2016;.
A growing number of natural products appear to arise from biosynthetic pathways that involve pericyclic reactions. We show here that for the heronamides this can occur via two spontaneous pathways involving alternative thermal or photochemical intramolecular cycloadditions.