Adverse effects of the SSRI antidepressant sertraline on early life stages of marine invertebrates.

Marine environmental research

PubMedID: 27255123

Estévez-Calvar N, Canesi L, Montagna M, Faimali M, Piazza V, Garaventa F. Adverse effects of the SSRI antidepressant sertraline on early life stages of marine invertebrates. Mar Environ Res. 2016;.
Widespread contamination of coastal environments by emerging compounds includes low concentrations of pharmaceuticals. These pollutants are not currently incorporated in monitoring programs despite their effects on non-target organisms are very little documented. Among the selective serotonin reuptake inhibitor (SSRI) antidepressants, sertraline (SRT) is one of the most prescribed globally. In this work, earlier life stages of Amphibalanus amphitrite, Brachionus plicatilis and Mytilus galloprovincialis were exposed to environmental concentrations of SRT in order to study both sub-lethal and lethal responses in 24/48 h-tests. Low concentrations of SRT altered significantly swimming behavior in A. amphitrite and B. plicatilis giving 48 h-EC50 (µg/L) of 113. 88 and 282. 23, respectively whereas higher values were observed for mortality and immobilization. EC50 embryotoxicity with M. galloprovincialis was 206. 80 µg/L. This work add new data about SRT ecotoxicity on marine invertebrates and confirms the applicability of behavioral endpoints to evaluate the environmental impact of antidepressants in marine organisms.