Rexinoids for prevention and treatment of cancer: opportunities and challenges.

Current topics in medicinal chemistry

PubMedID: 27320330

Liby KT, Sporn MB. Rexinoids for prevention and treatment of cancer: opportunities and challenges. Curr Top Med Chem. 2016;.
Rexinoids are selective ligands for the nuclear receptors known as RXRs. They do not bind to the receptors for all-trans-retinoic acid (RARs). Many new rexinoids have been synthesized and then assayed for their ability to suppress proliferation of cancer cells, to inhibit activation of inflammatory cells of the tumor microenvironment, and to prevent carcinogenesis in animal models relevant to human disease. Here we review the literature on the effects of 4 such rexinoids: bexarotene, LG100268, LG101506, and NRX194204. These rexinoids also have potent synergistic effects when used in combination with other active pharmacological agents, and practical clinical applications would benefit from these actions.