NOS Expression and NO Function in Glioma and Implications for Patient Therapies.

Antioxidants & redox signaling

PubMedID: 27411305

Tran AN, Boyd N, Walker K, Hjelmeland A. NOS Expression and NO Function in Glioma and Implications for Patient Therapies. Antioxid Redox Signal. 2016;.
SIGNIFICANCE
Gliomas are central nervous system tumors that primarily occur in the brain and arise from glial cells. Gliomas include the most common malignant brain tumor in adults known as grade IV astrocytoma, or glioblastoma (GBM). GBM is a deadly disease for which the most significant advances in treatment offer an improvement in survival of only ~2 months.

CRITICAL ISSUES
To develop novel treatments and improve patient outcomes, we and others have sought to determine the role of molecular signals in gliomas.

RECENT ADVANCES
One signaling molecule that mediates important biologies in glioma is the free radical nitric oxide (NO). In glioma cells and the tumor microenvironment, NO is produced by three isoforms of nitric oxide synthase (NOS), NOS1, NOS2, and NOS3. NO and NOS affect glioma growth, invasion, angiogenesis, immunosuppression, differentiation state, and therapeutic resistance.

FUTURE DIRECTIONS
These multifaceted effects of NO and NOS on gliomas both in vitro and in vivo suggest the potential of modulating the pathway for antiglioma patient therapies. Antioxid. Redox Signal. 00, 000-000.