[INTERACTION OF BETA-BLOCKER PROPRANOLOL WITH RENIN-ANGIOTENSIN SYSTEM INHIBITORS IN RAT KIDNEY].

Eksperimental'naia i klinicheskaia farmakologiia

PubMedID: 27455575

Kuzmin OB, Buchneva NV, Landar LN. [INTERACTION OF BETA-BLOCKER PROPRANOLOL WITH RENIN-ANGIOTENSIN SYSTEM INHIBITORS IN RAT KIDNEY]. Eksp Klin Farmakol. 2016;79(3):27-30.
Propranolol injection (0. 5 mg/kg, s. c. ) in anesthetized rats increases diuresis 1. 60 times (p < 0. 05) with simultaneous 1. 54- and 1. 62-fold increase (p < 0. 05) in sodium and potassium excretion, respectively. Preliminary inhibition of renin-angiotensin system (RAS) activity using ACE inhibitor enalapril (1 mg/kg, orally, 7 days) increases the sensitivity of rat kidney to drug, increasing its diuretic effect 2. 33 times, natriuresis 2. 49 times, and urine potassium excretion 1. 80 times (p < 0. 05). After the preliminary insertion of AT1 angiotensin receptor antagonist losartan (1 mg/kg, orally, 7 days), propranolol causes 1. 8-fold increase in diuresis, 2. 48-fold decrease in urine sodium, and 1. 71-fold decrease in kaliuresis (p < 0. 05). Preliminary administration of direct renin inhibitor aliskiren (4 mg/kg, orally, 7 days) is accompanied by 2. 30-fold increase in the diuretic effect of propranolol, 2. 56-fold increase in natriuresis, and 2. 27-fold increase in urine potassium excretion (p < 0. 05). It is concluded that the renal tissue RAS is involved in the mechanism of propranolol action in the kidney, acting as modulator preventing excessive loss of water and electrolytes with urine.