Executive dysfunction and survival in patients with amyotrophic lateral sclerosis: Preliminary report from a Serbian centre for motor neuron disease.

Amyotrophic lateral sclerosis & frontotemporal degeneration

PubMedID: 27494074

Stojkovic T, Stefanova E, Pekmezovic T, Peric S, Stevic Z. Executive dysfunction and survival in patients with amyotrophic lateral sclerosis: Preliminary report from a Serbian centre for motor neuron disease. Amyotroph Lateral Scler Frontotemporal Degener. 2016;1-5.
Our objective was to determine whether the presence of executive dysfunction in non-demented amyotrophic lateral sclerosis (ALS) patients might affect the longevity of survival. Forty-eight consecutive non-demented ALS patients (mean age =?52. 93?±?12. 37) were followed for five years. All patients underwent clinical and neuropsychological assessments at baseline visit. Further, a yearly follow-up check for associated dementia (ALS-Dem) was completed and the time of death was recorded, when applicable. Executive deficits were shown in 49. 5% of ALS patients, with the most striking differences found on the tests of verbal fluency (both phonemic and category, p?