A randomized controlled trial of smoking cessation methods in patients newly-diagnosed with pulmonary tuberculosis.

BMC infectious diseases

PubMedID: 27496096

Aryanpur M, Hosseini M, Masjedi MR, Mortaz E, Tabarsi P, Soori H, Emami H, Heidari G, Dizagie MK, Baikpour M. A randomized controlled trial of smoking cessation methods in patients newly-diagnosed with pulmonary tuberculosis. BMC Infect Dis. 2016;16369.
BACKGROUND
Tuberculosis (TB) and tobacco use are two major alarming global health issues that tend to be co-prevalent in many developing countries and various surveys have provided evidence on their entangled associations. Accordingly, it is strongly suggested that smoking cessation be incorporated in TB control programs. Therefore, we aimed to evaluate the effectiveness of two smoking cessation methods among newly-diagnosed pulmonary TB patients.

METHODS
A total of 210 newly-diagnosed pulmonary TB patients from Tehran, Iran with smoking habits were included in this randomized clinical trial during 2012-2013. Patients were assigned to three groups of control (just TB medical treatment), brief advice (TB medical treatment plus individualized counseling sessions of quitting behavioral therapy) and combined intervention (TB medical treatment plus individualized counseling sessions of quitting behavioral therapy plus medical treatment with slow release bupropion). Patients' abstinence was followed at six time point during six months. Data were analyzed by SPSS v.22 using Generalized Estimating Equations (GEE) model.

RESULTS
Abstinance rate at the end of six months were 71.7 % for combined intervention group, 33.9 % for brief advice group and 9.8 % for the control group (p?
CONCLUSION
Considering the prevalence and importance of TB and the substantial influence of these preventive measures on controlling tobacco use, application of such programs is recommended.

TRIAL REGISTRATION
The survey was registered in the Iranian registry of clinical trials website (irct.ir) in August 31, 2013 with IRCT ID: IRCT2013062613783N1 .