Association of T Cell and Macrophage Activation with Arterial Vascular Health in HIV.

AIDS research and human retroviruses

PubMedID: 27527002

Grome HN, Barnett L, Hagar CC, Harrison DG, Kalams S, Koethe JR. Association of T Cell and Macrophage Activation with Arterial Vascular Health in HIV. AIDS Res Hum Retroviruses. 2016;.
HIV-infected individuals are at increased risk of cardiovascular disease (CVD), but the arterial vascular functions affected by persistent innate and cellular immune activation are not well described. We assessed the relationship between immunologic and vascular parameters in 70 HIV-infected adults on efavirenz, tenofovir, and emtricitabine with more than 2 years of virologic suppression and no history of CVD. We measured brachial artery flow-mediated dilation (FMD) using ultrasound and circulating intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) by multiple immunoassay. We also measured circulating naive (CD45RO(-)CCR7(+)CD27(+)), activated (CD38(+) and CD38(+)DR(+)), exhausted (PD1(+)), senescent (CD57(+)), and memory (CD45RO(+)) CD4(+) and CD8(+) T cell subsets by flow cytometry, and macrophage activation markers by ELISA and multiple immunoassay. Regression models were adjusted for age, sex, smoking, duration of antiretroviral therapy (ART), and body mass index. Median age was 45 years (IQR 39, 50), median CD4(+) count 701 cells/┬Ál (IQR 540, 954), and 43% were female. Lower brachial FMD was associated with a higher percentage of activated CD8(+) T cells (p?<. 01), but not associated with macrophage activation. In contrast, higher ICAM-1 and VCAM-1 were associated with sCD163 (p?