Nucleolar Methyltransferase Fibrillarin: Evolution of Structure and Functions.

Biochemistry. Biokhimiia

PubMedID: 27682166

Shubina MY, Musinova YR, Sheval EV. Nucleolar Methyltransferase Fibrillarin: Evolution of Structure and Functions. Biochemistry Mosc. 2016;81(9):941-50.
Fibrillarin is one of the most studied nucleolar proteins. Its main functions are methylation and processing of pre-rRNA. Fibrillarin is a highly conserved protein; however, in the course of evolution from archaea to eukaryotes, it acquired an additional N-terminal glycine and arginine-rich (GAR) domain. In this review, we discuss the evolution of fibrillarin structure and its relation to the functions of the protein in prokaryotes and eukaryotes.