Context-Dependent Egr1 Expression in the Avian Hippocampus.

PloS one

PubMedID: 27716817

Grella SL, Guigueno MF, White DJ, Sherry DF, Marrone DF. Context-Dependent Egr1 Expression in the Avian Hippocampus. PLoS ONE. 2016;11(10):e0164333.
In mammals, episodic memory and spatial cognition involve context-specific recruitment of unique ensembles in the hippocampal formation (HF). Despite their capacity for sophisticated spatial (e. g. , for migration) and episodic-like (e. g. , for food-caching) memory, the mechanisms underlying contextual representation in birds is not well understood. Here we demonstrate environment-specific Egr1 expression as male brown-headed cowbirds (Molothrus ater) navigate environments for food reward, showing that the avian HF, like its mammalian counterpart, recruits distinct neuronal ensembles to represent different contexts.