Comparative study between 2 different doses of pregabalin and lidocaine on pain following propofol injection: A double-blind, randomized clinical consort study.

Medicine

PubMedID: 28002316

Choi E, Kim D, Jeon Y. Comparative study between 2 different doses of pregabalin and lidocaine on pain following propofol injection: A double-blind, randomized clinical consort study. Medicine (Baltimore). 2016;95(51):e5153.
BACKGROUND
Propofol, an intravenous anesthetic, often causes pain on injection, which can be very distressful to patients. We investigated the analgesic effect of pregabalin on pain following propofol injection, compared with lidocaine.

METHODS
In a randomized, double-blind, prospective trial, 120 patients were randomized into 3 groups of 40 each; who received oral placebo and intravenous lidocaine 40?mg with venous occlusion for 1 minute (group L, n?=?40), oral pregabalin 75?mg and intravenous normal saline with venous occlusion for 1 minute (group LP, n?=?40), and oral pregabalin 150 mg and intravenous normal saline with venous occlusion for 1 minute (group HP, n?=?40) as pretreatment, followed by administration of 1% propofol 0.5?mg/kg. Pain intensity was measured on a 4-point scale (0?=?no, 1?=?mild, 2?=?moderate, and 3?=?severe pain). Any side effects associated with pretreatment substances were recorded during the first 24 hours after surgery.

RESULTS
A total of 120 patients completed this trial. Demographic data were similar between groups. The incidence of pain following propofol injection was significantly reduced in group HP (50%) and group L (55%) compared with group LP (92.5%) (P?
CONCLUSION
Pretreatment with oral pregabalin 150 mg and intravenous lidocaine 40?mg with venous occlusion equally reduced pain from propofol injection.