The Polyherbal Wattana Formula Displays Anti-Amyloidogenic Properties by Increasing a-Secretase Activities.

PloS one

PubMedID: 28107420

Htoo HH, Limsuvan S, Thamsermsang O, Hernandez JF, Checler F, Govitrapong P, Pakaprot N, Akarasereenont P, Vincent B. The Polyherbal Wattana Formula Displays Anti-Amyloidogenic Properties by Increasing a-Secretase Activities. PLoS ONE. 2017;12(1):e0170360.
Alzheimer's disease is characterized by the deposition of insoluble amyloid-ß peptides produced from the ß-amyloid precursor protein (ßAPP). Because a-secretase cleavage by ADAM10 and ADAM17 takes place in the middle of Aß, its activation is considered as a promising anti-AD therapeutic track. Here we establish that the polyherbal Wattana formula (WNF) stimulates sAPPa production in cells of neuronal and non-neuronal origins through an increase of both ADAM10 and ADAM17 catalytic activities with no modification of BACE1 activity and expression. This effect is blocked by specific inhibition or genetic depletion of these disintegrins and we show that WNF up-regulates ADAM10 transcription and ADAM17 maturation. In addition, WNF reduces Aß40 and Aß42 generation in human cell lines. Altogether, WNF presents all the characteristics of a potent preventive anti-Alzheimer formula. Importantly, this natural recipe, currently prescribed to patients for the treatment of other symptoms without any secondary effect, can be tested immediately for further clinical studies.