Effect of Gender Differences on Transplant Kidney Function.

Transplantation proceedings

PubMedID: 28104160

Yoneda T, Iemura Y, Onishi K, Hori S, Nakai Y, Miyake M, Anai S, Torimoto K, Aoki K, Saka T, Tanaka N, Yoshida K, Fujimoto K. Effect of Gender Differences on Transplant Kidney Function. Transplant Proc. 2017;49(1):61-64.
BACKGROUND
Transplant kidney function is thought to be affected by sex differences, such as physical conditions including muscle volume, sex hormones, immune responses, and so forth. We examined the effect of sex differences on transplant kidney function.

METHODS
The subjects were selected from kidney transplant recipients, who received kidney transplantation on our hospital between January 2000 and August 2015. Cadaveric donors and parent-child pairs with an age difference were excluded, then we included 47 recipients whose sex was different from the sex of the donor. We compared transplant kidney function between male donors and female recipients group (M?F, n = 20) and female donors and male recipients group (F?M, n = 27).

RESULTS
Nadir creatinine value was higher in the F?M group than in the M?F group (1.09 mg/dL vs 0.76 mg/dL, P < .0001). The estimated glomerular filtration rate (eGFR) was significantly higher in the M?F group than in the F?M group (66.6 mL/min/1.73 m(2) vs 50.1 mL/min/1.73 m(2), P = .002), and eGFR ratio (recipient to donor) was significantly higher in the M?F group than in the F?M group (1.13 vs 0.57, P < .0001). Multiple linear regression analysis showed that the only the sex of the recipient was significant prognostic factor of eGFR after renal transplantation (P = .037).

CONCLUSIONS
The short-term kidney function of the graft from male to female was better than that of the graft from female to male.