Liver Transplantation for Biliary Rhabdomyosarcoma With Liver Metastasis: Report of One Case.

Transplantation proceedings

PubMedID: 28104133

Shen CH, Dong KR, Tao YF, Chen G, Li RD, Zhang QB, Zhang XF, Zheng S, Wang ZX. Liver Transplantation for Biliary Rhabdomyosarcoma With Liver Metastasis: Report of One Case. Transplant Proc. 2017;49(1):185-187.
BACKGROUND
Liver transplantation in combination with chemotherapy in postoperative biliary rhabdomyosarcoma recurrence of children was evaluated.

METHODS
An 8-year-old girl with biliary rhabdomyosarcoma underwent pancreatico-duodenectomy with postoperative vincristine (VCR), adriamycin (Act-D), and cyclophosphamide (CTX) (VAC chemotherapy) (VCR, 1 mg; Act-D, 0.7 mg; CTX, 1500 mg). Two years later, liver metastasis in the left and right lobes was found and was followed by VAC chemotherapy (CTX, 1800 mg; Act-D, 0.9 mg; VCR, 1.2 mg), with no change of the tumor size. One and a half years later, liver transplantation performed with postoperative pathology confirmed embryonal rhabdomyosarcoma recurrence and was followed by VAC chemotherapy (CTX, 1400 mg; Act-D, 0.7 mg; VCR, 1.9 mg) and immunosuppression treatment.

RESULTS
The liver transplantation went well, with no major complications. At the time of this report, the patient had survived for 6 months, with a good quality of life and no tumor recurrence.

CONCLUSIONS
For unresectable biliary rhabdomyosarcoma without extra-hepatic metastases, liver transplantation could be an effective treatment. Liver transplantation completely removes the tumor and reduces the long-term side effects of chemotherapy drugs.