RISK FACTORS ASSOCIATED WITH FAILURE OF EXTUBATION IN VERY-LOW-BIRTH-WEIGHT NEWBORNS.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

PubMedID: 28118771

Spasojevic S, Doronjski A. RISK FACTORS ASSOCIATED WITH FAILURE OF EXTUBATION IN VERY-LOW-BIRTH-WEIGHT NEWBORNS. J Matern Fetal Neonatal Med. 2017;1-13.
AIM
To identify risk factors associated with the failure of extubation of mechanically ventilated very-low-birth-weight newborns.

STUDY DESIGN
Prospective observational study. Assessment of the occurrence of extubation failure in relation to demographic and ventilation parameters, the SpO2/FiO2 ratio, the spontaneous breathing test (SBT) and values of the Silverman-Andersen score (SAS). Extubation failure was defined as the need for reintubation for any reason within 72?hours after extubation.

RESULTS
Extubation failed in 14/50 (28%) patients. Tidal volume applied at the moment of extubation (p?=?0.030), the values of the SpO2/FiO2 ratio (p?=?0.006), SBT (p?=?0.034) and SAS measured for 60?minutes after extubation and later (p?=?0.010, p?=?0.000001, p~0.000, respectively) showed a significant association with reintubation.

CONCLUSION
Measured TV, SpO2/FiO2 ratio, SBT at the moment of extubation and values of SAS starting 1?hour after extubation might be valuable parameters in identifying those VLBW newborns in the risk to fail extubation.