[Influence of n-hexane on vascular endothelial active substances in brain tissue in mice].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

PubMedID: 28241704

Lin L, Zhang ZQ, Zhang CZ. [Influence of n-hexane on vascular endothelial active substances in brain tissue in mice]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2017;35(1):49-50.
OBJECTIVE
To investigate the influence of n-hexane on vascular endothelial active substances in brain tissue in mice and its significance.

METHODS
A total of 48 healthy Kunming mice were randomly divided into high-dose exposure group, middle-dose exposure group, low-dose exposure group, and control group, with 12 mice in each group.All groups except the control group were exposed to n-hexane via static inhalation (0. 035 g/L, 0. 018 g/L, and 0. 009 g/L for the high-, middle-, and low-dose exposure groups, respectively) 4 hours a day for 21 days. the mice in the control groups were not exposed to n-hexane. After the exposure, the lev-els of endothelin-1 (ET-1) , nitric oxide (NO) , and angiotensin II (Ang II) in brain tissue were measured in all groups.

RESULTS
There were significant differences in the levels of ET-1, NO, and Ang II between the three ex-posure groups and the control group (P<0.05). Compared with the control group, the high-and middle-dose expo-sure group had significant increases in the levels of ET-1 and Ang II and the high-dose exposure group had a sig-nificant reduction in the level of NO (P<0. 05 or P<0. 01).

CONCLUSION
n-Hexane can affect the vascular endothe-lial active substances in brain tissue in mice, and the changes and imbalance in vascular endothelial active sub-stances may be one of the reasons for central nervous system impairment caused by n-hexane.