[Advances in clinical research on rtA181 mutation in hepatitis B virus].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

PubMedID: 28297788

Gong XL, Liu R, Liu YX, Zhang Y. [Advances in clinical research on rtA181 mutation in hepatitis B virus]. Zhonghua Gan Zang Bing Za Zhi. 2017;25(1):69-72.
Nowadays, nucleos(t)ide analogues (NAs) are important drugs for the treatment of chronic hepatitis B and can suppress the virus through inhibiting the activity of hepatitis B virus (HBV) polymerase. However, rtA181 mutation in HBV can reduce the sensitivity of HBV to various NAs, which brings new challenges to antiviral therapy. This article briefly introduces the research advances in the clinical detection rate of rtA181 mutation and its influence on therapeutic effect and prognosis.